HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Miller, J. K. Articles by Byrne, W. F. Search for Related Content PubMed PubMed Citation Articles by Miller, J. K. Articles by Byrne, W. F.

Absorption, Excretion, and Tissue Distribution of Orally and Intravenously administered Radiocerium as Affected by EDTA¹

Agricultural Research Laboratory of the University of Tennessee, Oak Ridge 37830

ABSTRACT

Three pairs of calves fed 0, 1.35, or 13.5 g ethylenediaminetetraacetic acid (EDTA) per calf by capsule daily and one pair fed 13.5 g EDTA in milk through nipple pails were given intravenous ¹⁴¹Ce and oral ¹⁴⁴Ce as simultaneous single doses. Oral ¹⁴⁴Ce could not be detected in blood and intravenous ¹⁴¹Ce cleared rapidly with less than 16 and 0.6% remaining in blood 1 and 24 hours after dosing. Urinary ¹⁴⁴Ce increased from 0.01% of the oral dose for controls to 0.21% when 1.35 g EDTA was fed. Percentages of the ¹⁴⁴Ce dose in urine were further increased to 0.56 for calves fed 13.5 g EDTA by capsule and 1.21% for calves fed 13.5 g by nipple pail. Urinary ¹⁴¹Ce was raised slightly from 1.2% of the intravenous dose for controls to 1.6 by 1.35 g EDTA, to 5.27% by 13.5 g in gelatin capsules, and to 9.75% by 13.5 g given through nipple pails. Entry of intravenous ¹⁴¹Ce into the digestive tract occurred primarily in the small intestine. Fecal excretions and tissue distributions of both oral and intravenous doses were not statistically significantly changed by EDTA. Average 72-hour fecal excretions totaled 94 and 2% for oral and intravenous doses. Tissue ¹⁴¹Ce, expressed as percentages of the intravenous dose per 100 g, averaged: heart, 0.04; femur, 0.41; kidney, 0.23; liver, 2.60; lung, 0.75; rib, 0.13; and spleen, 0.67. Oral ¹⁴⁴Ce was not detected in any tissue except the liver, which averaged 0.7% of the oral dose compared to 36.7% of the intravenous dose.

¹ This manuscript is published with the permission of the Director of the University of Tennessee Agricultural Experiment Station, Knoxville.