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Metabolism of Radioiodide by Lactating Goats Given Iodine-131 for Extended Periods¹

Department of Physical Biology, New York State Veterinary College, Cornell University, Ithaca, New York 14850

ABSTRACT

Twenty-two goats were given twice-daily doses of ¹³¹I to determine distribution of radioiodine into milk, urine, feces, and thyroids as these animals approached steady state. For 16 goats on the control diet 36.7 and 5.6% of a daily dose of ¹³¹I per liter was found in the milk and plasma, respectively. The ¹³¹I milk-plasma ratio was 7.6. Supplementing the control diet with 4 mg of iodine per day resulted in a reduction of thyroid ¹³¹I and an increase in milk ¹³¹I in milk, whereas 1.2 g of KI per day markedly reduced the ¹³¹I in milk and reduced the M/P ratio by a factor of 10. Perchlorate, fluoroborate, thiourea, Chlorothiazid, and thyroxine reduced the iodine concentration in milk. Though the ability of the goat to concentrate iodide in milk is greater than for the cow, the mechanisms of concentration appear to be similar.

¹ Supported in part by Contract AT (30-1)-2147 with the U.S. Atomic Energy Commission and the United States Department of Agriculture 12-14-100-2599(45).