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Effects of Secret in and Cholecystokinin-Pancreozymin on Pancreatic Juice and Insulin Secretion of Goats

Department of Nutrition, School of Public Health, Harvard University, Boston, Massachusetts 02115

ABSTRACT

Goats injected intravenously with as much as 3.75 clinical Units of secretin per kilogram body weight did not show an increased serum immunoreactive insulin level. An intravenous injection of 5.6 Crick Units of cholecystokinin-pancreozymin per kilogram caused an immediate doubling of the serum immunoreactive insulin level, which returned to near normal after 3 to 5 min. The maximum dose tested of secretin was several times higher than that required to cause the response in other species; the cholecystokinin-pancreozymin dose caused less of a response in goats than in monogastric animals. The highly purified secretin and cholecystokinin-pancreozymin hormone preparations were also shown to have a marked effect on the exocrine function of the pancreas at doses less than those tested above. Therefore, although secretin and cholecystokinin-pancreozymin cause exocrine secretion of the pancreas similar to that in monogastrics, only cholecystokinin-pancreozymin causes insulin secretion in goats.