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Metabolism of 3,5-Diiodosalicylic Acid in Cattle and Rats

Metabolism and Radiation Research Laboratory, Animal Husbandry Research Division, USDA, Fargo, North Dakota

ABSTRACT

The metabolic fate of carboxyl ¹⁴C-diiodosalicylic acid (DIS) was studied in cattle and rats. In three trials with cattle, approximately 95% of ¹⁴C was excreted via the urine within ten days of dosing. Diiodosalicylic acid and 5-iodosalicylic acid were the only metabolites in cattle urine, with ratios of DIS:5-iodosalicylic acid from 1.1 to 7.8. There was considerable variation in excretion and relative amounts of metabolites of ¹⁴C-DIS in rats. Radioactive DIS, 5-iodosalicylic acid, 3-iodosalicylic acid, salicylic acid, and salicyluric acid were identified in rat urine. In some trials salicyluric acid and 5-iodosalicylic acid were the major metabolites, and approximately 80% of the dose was excreted via the urine within 72 hours after dosing. In other trials very little salicyluric acid was found, and DIS and 5-iodosalicylic acid were the major metabolites. In the latter case, the feces became an important excretory route as intake of stable DIS reached 5 mg/kg per day. Diiodosalicylic acid was the major fecal metabolite.

Cattle have less ability than rats to remove iodine from DIS, explaining why it is unsatisfactory as an iodine carrier in trace mineral salt for cattle, even though it has proved effective in rats.