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Journal of Dairy Science Vol. 50 No. 9 1486-1494
© 1967 by American Dairy Science Association ®
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Rates of Formation and Absorption of Cerebrospinal Fluid in Bovine Hypovitaminosis A1

M. C. Calhoun2, H. D. Hurt, H. D. Eaton, J. E. Rousseau, Jr. and R. C. Hall, Jr.

Animal Nutrition, Animal Industries Department, Storrs (Conn.) Agricultural Experiment Station, Storrs

ABSTRACT

Ventriculocisternal perfusion (VCP) was used to determine the rates of bulk absorption (inulin clearance, CIn) and formation (Vf) of cerebrospinal fluid (CSF) in nine hypovitaminotic A and ten vitamin A adequate calves. The average intraventricular CSF pressures were 374 and 54 mm of synthetic CSF for the deficient and adequate calves, respectively, with corresponding plasma vitamin A concentrations of 5 and 29 µg/100 ml. Regressions of CIn and Vf, both in g/min, on perfusion pressure (–100, 0, or +200 mm of synthetic CSF relative to the initially determined CSF pressure), X, were, respectively, for the deficient and adequate calves : CIn = 0.258 + 0.00062 X and CIn = 0.318 + 0.00111 X (SD = 0.038) ; Vf = 0.312 – 0.00016 X and Vf = 0.328 – 0.00030 X (SD = 0.034). The magnitude of the response to the induced VCP pressures was significantly less for CIn in the deficient calves; whereas, for Vf, differences were not significant. Thus, absorption of CSF is impaired in hypovitaminotic A calves.

FOOTNOTES

1 Scientific contribution no. 270, Agricultural Experiment Station, University of Connecticut, Storrs. This investigation was supported in part by grant-in-aid funds provided by a Public Health Service Research Grant, RO1 NB-02108-07, from The National Institute of Neurological Diseases and Blindness, and by Agway, Inc., Syracuse, N. Y., Hoffmann-LaRoche, Nutley, N. J., and Wirthmore Feeds, Inc., Waltham, Massachusetts.

2 Present address: Animal Science and Agricultural Biochemistry Department, University of Delaware, Newark, Delaware 19711.






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Copyright © 1967 by the American Dairy Science Association ®.