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Drug Movement between Bovine Milk and Plasma as Affected by Milk pH¹

Department of Veterinary Physiology and Pharmacology and Department of Animal Science, University of Minnesota, St. Paul

ABSTRACT

As part of a study on non-ionic diffusion of drugs into milk, salicylic acid, paminohippuric acid, sulfacetamide, sulfamerazine, sulfamethazine, sulfathiazole, sulfapyridine, sulfanilamide, and phenol were infused into lactating cows, to maintain constant plasma concentrations for 6 hr. The right front quarter of each cow was infused with sterile bicarbonate buffer solution to establish a pH value of 8.0. Blood, milk from the normal quarters, and milk from the bicarbonate-treated quarters were sampled simultaneously at hourly intervals. The weak organic bases, urea, antipyrine, creatinine, aminopyrine, quinine, and ephedrine were studied in like manner. Experimentally determined milk-to-plasma ultrafiltrate ratios agreed well with theoretical ratios for non-ionic diffusion both in the normal and in bicarbonate-treated quarters. It was concluded that the passage of these compounds into bovine milk can be explained by passive diffusion.

¹ This project is supported by National Institute of Health Grant no. EF-00481-03. Scientific Journal Series paper no. 6165, Minnesota Agricultural Experiment Station.