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Passage of Pentobarbital and Phenobarbital into Bovine and Caprine Milk after Systemic Administration^{1, 2,}

Department of Veterinary Physiology and Pharmacology, Department of Animal Science, University of Minnesota, St. Paul

ABSTRACT

Conclusion: Under equilibrium conditions, it appears that pentobarbital passes into the milk of cows and goats in accord with pH partition concepts. It would be desirable to study wider ranges of pentobarbital concentrations, to test a possible loading effect.

Phenobarbital also appears to enter the milk of the goat via passive diffusion. Here a wide range of plasma concentrations could be studied and no loading of a possible carrier system could be demonstrated.

¹ This project is supported by National Public Health Service Grant no. EF-00481-03.

² Scientific Journal Series Paper no. 6164, Minnesota Agricultural Experiment Station.