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Placement of Electrodes in the Hypothalamus of Goats¹

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

ABSTRACT

A technique is described that makes possible the stimulation of hypothalamic centers in goats. Since stereotaxic atlases are not available for the larger domestic animals, probes must be functionally placed. A Plexiglass plate containing 102 guide cannulas in a 2.0- by 2.5-cm area is surgically placed on the skull in such a way that the center block of the guide plate rests on the dura. Postoperatively in the unanesthetized goats, probes can be inserted through the cannulas. By means of the one surgical operation, various responses can be induced by the required functional placement of probes. Some of the responses of hypothalamic stimulation and other uses of the preparation are discussed.

¹ This study was supported in part by grants in aid from the National Institute of Neurological Diseases and Blindness (NB 01941), National Institutes of Health, Bethesda, Maryland; from the National Science Foundation (GB 4594) ; and from the Fund for Research and Teaching of the Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts. C. A. B. was the holder of a postdoctoral fellowship, supported in part by the National Institute of Child Health and Human Development.