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Acetone Metabolism in Normal and Ketotic Cows¹

College of Agriculture and School of Veterinary Medicine, University of California, Davis

ABSTRACT

Acetone-2-C¹⁴ was injected intravenously into two spontaneously ketotic cows and one cow fasted for five days, and into all three cows when lactating normally. Peaks in specific activity of respired CO₂ and plasma glucose occurred 2 hr later. The standardized specific activity was higher in lactose than in casein or milk fat in all cows, for both the normal and ketotic states. Although the pattern of distribution of C¹⁴ among the various products was the same in normal and ketotic cows, the over-all recovery of C¹⁴ was only about one-tenth as great in ketotic cows as in normal cows. The data are consistent with acetone metabolism being predominantly glucogenic but quantitatively unimportant in both normal and ketotic cows.

¹ This research was supported by a contract with the U.S. Atomic Energy Commission and by a grant from the National Institute of Health, GM-08183.

² Present address: Institute of Arctic Biology, University of Alaska, College, Alaska 99735.

³ On leave from the Royal Veterinary and Agricultural College, Copenhagen. Appointment supported by the International Co-operation Administration, Visiting Research Scientist program, administered by the National Academy of Sciences, U.S.A.

⁴ Kellogg Fellow, present address: Department of Agricultural Chemistry, University of Tokyo, Tokyo, Japan.

⁵ Present address: University of Pennsylvania, School of Veterinary Medicine, Kennett Square, Pennsylvania.