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Department of Dairy Science, The Ohio Agricultural Research and Development Center, Wooster, Ohio;
The Ohio State University, Columbus, Ohio;
and USDA, Beltsville, Maryland
ABSTRACT
The effects of ovariectomy on the activities of glucose-6-phosphate dehydrogenase (EC 1.1.1.49), 6-phosphogluconate dehydrogenase (EC 1.1.1.44), and NADP+-malic dehydrogenase (EC 1.1.1.40) in the rat mammary gland during lactation were evaluated. The effects of estradiol and progesterone were also assessed. Ovariectomy reduced the activities of these enzymes which were found to be normally at their highest activity on the fifteenth day of lactation. Ovariectomy prevented the characteristic decrease in the enzyme activities following their peak at the fifteenth day. Estradiol was found to elevate the total activity of all three enzymes in the mammary glands of ovariectomized rats in their tenth day of lactation. Progesterone increased the activities of all three enzymes in this organ, but the increase was generally less than that caused by estradiol.
1 A contribution from the NC-2 Dairy Cattle Breeding Project in cooperation with the Dairy Genetics and Breeding Section of the Dairy Husbandry Research Branch, USDA, Beltsville, Maryland. Journal Article no. 43–66.
2 Present address: Departments of Biochemistry and Obstetrics and Gynecology, University of Nebraska College of Medicine, Omaha.
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