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Rates of Formation and Absorption of Cerebrospinal Fluid in Chronic Bovine Hypervitaminosis A¹

Animal Nutrition, Animal Industries Department, Storrs (Conn.) Agricultural Experiment Station, Storrs

ABSTRACT

Ventriculocisternal perfusion (VCP) of eight control and six chronic hypervitaminotic A Holstein male calves was conducted to estimate the rates of formation (_f) and bulk absorption (inulin clearance, C_In) that are associated with the lower cerebrospinal fluid (CSF) pressures observed in experimental hypervitaminosis A. The control and hypervitaminotic A calves received 108 and 10,800 µg of retinol (as vitamin A acetate)/kg live wt/day and were 147 and 146 ± 2 days of age, weighed 103 and 89 ± 10 kg with plasma vitamin A concentrations of 29.6 and 125.0 µg/100 ml, respectively. Initial intraventricular (IV) CSF pressures relative to the site of IV cannulation were -13 and -55 mm of synthetic CSF for the control and hypervitaminotic A groups, respectively. _f, in grams per minute, was unaffected by the imposed perfusion pressure and equalled 0.342 ± 0.059 for the control calves and 0.236 ± 0.059 for the hypervitaminotic A calves. Regression of C_In in g/min on imposed perfusion pressure (0 or +200 mm of synthetic CSF) relative to the initial IV pressure, X, for the control calves was: C_In = 0.324 + 0.00159 X ± 0.095 and for the hypervitaminotic A calves, C_In = 0.322 + 0.00212 X ± 0.095. The lower CSF pressure of the chronic hypervitaminotic A calf is apparently due in part to a reduced rate of formation of CSF and possibly to a decreased resistance to bulk absorption.

¹ Scientific contribution no. 287, Agricultural Experiment Station, University of Connecticut, Storrs. This study was supported in part by grant-in-aid funds provided by PHS research grant RO1 NB-02108-08, from the National Institute of Neurological Diseases and Blindness and by Agway, Inc., Syracuse, N. Y., Hoffmann-La Roche, Nutley, N. J., and Wirthmore Feeds, Inc., Waltham, Mass.

² Present address: Animal Science Department, Morrison Hall, Cornell University, Ithaca, N. Y. 14850.