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Metabolism of Oral Iodide and 3,5-Diiodosalicylic Acid in the Pregnant Cow¹

Agricultural Research Laboratory of the University of Tennessee, Oak Ridge⁴

ABSTRACT

Three near-term pregnant cows were studied. Two of these were each given simultaneous oral tracer doses of I¹³¹ as 3.5-diiodosalicylic acid (DI¹³¹S) and I¹²⁵. The third cow was given both radioisotopes as iodide. One was sacrificed at 144 and two at 168 hr after dosage. For the animals given DI¹³¹S, the percentage of dose of each isotope excreted (urinary and fecal) in 144 hr was I¹³¹, 83.6%; I¹²⁵, 43.1%. The average percentage of the dose in the thyroids at the time of sacrifice was I¹³¹ in the maternal thyroid, 2.3%; I¹³¹ in the fetal a thyroid, 2.1%; I¹²⁵ in the maternal thyroid, 18.0%; I¹²⁵ in the fetal thyroid, 15.9%. Iodine fed as DIS was not as available to either maternal or fetal thyroid and did not cross the placenta as readily as iodine fed as iodide. The animal given both isotopes as iodide exhibited no differences between the two isotopes in excretion or in concentrations in the various tissues.

¹ This manuscript is published with permission of the Director of the University of Tennessee Agricultural Experiment Station, Knoxville.

² Metabolism and Radiation Laboratory, State University Station, Fargo, South Dakota.

³ Dairy Department, University of Tennessee, Knoxville.

⁴ Operated by the Tennessee Agricultural Experiment Station for the U. S. Atomic Energy Commission under Contract no. AT-40-1-GEN-242.