HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Perry, S. C. Articles by Short, C. E. Search for Related Content PubMed Articles by Perry, S. C. Articles by Short, C. E.

Effects of Parathyroid Extract on Removal of Sr⁸⁹, Ca⁴⁵, and P³² by Hemodialysis from Conscious Calves¹

Agricultural Research Laboratory, The University of Tennessee, Oak Ridge^,5

ABSTRACT

Effects of parathyroid hormone on mobilization of Sr, Ca, and P were studied by hemodialysis. Nine fasted calves were randomly assigned to one of three treatment groups. Treatments were: (A) thyroparathyroidectomy, (B) thyroparathyroidectomy plus PTE, and (C) control mock-operated calves. Strontium-89, Ca⁴³, and P³² were injected intravenously 48 hr before the 16-hr dialysis period. Surgery was performed 22 hr before dialysis. The PTE was given intramuscularly at 2-hr intervals, beginning at the initiation of dialysis (6.6 USP units/ kilogram/day).

Treatments did not significantly affect the accumulation of total Ca or P in the dialyzing baths. However, the Sr⁸⁹/Ca⁴⁵ ratio of activities in the baths was significantly increased by PTE administration (P < .05). Reduction of plasma Ca⁴⁵ activity during dialysis averaged (A) 28%, (B) 53%, and (C) 51% (A vs. B + C, P < 0.05). Treatment of the animals with PTE significantly reduced Sr⁸⁹ in epiphyseal bone (P < 0.05). All treatments resulted in an incorporation of Ca⁴⁵ into the rib epiphyses. The PTE group (B) had the greatest reduction of Sr⁸⁹ activity and also the greatest incorporation of Ca⁴⁵ into the rib epiphyses during dialysis. Accumulation of Sr⁸⁹ and Ca⁴⁵ in the dialyzing baths, reduction of Ca⁴⁵ activity in the plasma, and the relative Sr⁸⁹ and Ca⁴⁵ activities of the rib epiphyses indicate that PTE administration resulted in a release of Sr⁸⁹ from the epiphyses, with a preferential incorporation of Ca⁴⁵ during dialysis.

¹ This manuscript is published with permission of the Director of the University of Tennessee Agricultural Experiment Station, Knoxville, and the Director of the Maryland Agricultural Experiment Station, College Park. University of Maryland Scientific Article no. A1235, Contribution no. 3740.

² Oak Ridge Institute of Nuclear Studies (ORINS) Fellow 1963–64. Present address: Department of Physiology and Biophysics, University of Illinois, Urbana.

³ Department of Dairy Science, University of Maryland, College Park.

⁴ Post-graduate Fellow, Physiology Department, Baylor University Medical School, Houston, Texas.

⁵ Operated by the Tennessee Agricultural Experiment Station for the U. S. Atomic Energy Commission under Contract no. AT-40-1-GEN-242.