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Journal of Dairy Science Vol. 49 No. 11 1350-1356
© 1966 by American Dairy Science Association ®
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Antigenicity and Ability of Lactic Streptococcal Bacteriophage to Penetrate Skins of Rabbits and Mice1

F. W. Bennett and J. W. Foster

Departments of Dairy Science, and Microbiology and Preventive Medicine, University of Georgia, Athens

ABSTRACT

The antiphage titers of blood sera from rabbits intradermally inoculated with, or exposed to aerosols of, lactic streptococcal bacteriophage were measured and counts made of the phage particles in cardiac blood samples from mice whose tails were exposed to whey lysates containing the phage. Blood sera from the intradermally inoculated rabbits reduced the active phage particles in equal volumes of phage suspensions as much as 8 logs. This neutralizing ability varied among individual rabbits, with the number and size of the inocula and the time elapsing after the initial inoculation. The numbers of phage particles, if any, penetrating the skin and mucous membranes of rabbits exposed to aerosols three times per week for over eight months were too small to cause a significant neutralizing titer in their blood sera.

The passage of lactic streptococcal phage through the intact skin was studied by immersing the tails of white Swiss mice for 15 min in phage-containing whey filtrates. Phage particles were not recovered from 62% of the cardiac blood samples taken from the mice within 2 hr of the immersion of their tails. The over-all average phage count of blood samles was 115/milliliter and the maximum individual count 950/milliliter.

FOOTNOTES

1 Journal Paper no. 465 of the College Experiment Station, University of Georgia College Experiment Station.






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Copyright © 1966 by the American Dairy Science Association ®.