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Response of Various Rat Liver Mitochondrial Enzymes to Different Amounts of Iodinated Casein in the Diet^{1, 2}

Department of Dairy Science, Ohio Agricultural Experiment Station, Wooster

ABSTRACT

In 1957, Maley (7), found that liver mitochondrial enzymes involved in glutamate oxidation, succinoxidase, cytochrome oxidase, cytochrome c, and ATP-ase, were higher in thyrotoxic rats than in normal rats. Further evidence that rat liver enzymes were induced by thyroxine was found by Dosta (3) in 1963, working with glucose 6-phosphatase and by Tepperman (10) in 1964 working with the malic enzyme. Westerfeld et al. (12) in 1963 reported a sevenfold increase in alpha-glycero-phosphate dehydrogenase (alpha,-GPD) when rats were fed diets containing 0.025% iodinated casein (I.C.).

In the experiments reported here the response to four levels of I.C. fed for different periods of time of five different rat liver mitochondrial enzymes was measured. The objective was to evaluate the different enzyme responses to thyroxine and to assess these responses as possible measures of degree of thyrotoxicosis.

EXPERIMENTAL PROCEDURES

Sixty female weanling rats (Carworth) weighing between 45–60 g were divided into 20 groups of three and fed an exclusive whole milk diet supplemented daily with iron (5 mg/kg body weight), magnesium (5 mg/kg body weight), and copper (2 mg/kg body weight).

¹ The data reported here are from a doctoral dissertation presented in partial fufillment of requirements for the Ph.D. Degree, The Ohio State University. 1964.

² Approved for publication as Journal Article No. 37-65, by the Associate Director of the Ohio Agricultural Experiment Station, Wooster.