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Journal of Dairy Science Vol. 48 No. 3 381-390
© 1965 by American Dairy Science Association ®
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Metabolism of N-Butyrate by the Adult Goat1

H. A. Ramsey2 and C. L. Davis

Department of Dairy Science, University of Illinois, Urbana

ABSTRACT

N-butyrate-1-C14 was injected intravenously into four adult goats. Observations were made on the subsequent incorporation of C14 into liver and muscle glycogen and into various organic acids of blood, taken either from the jugular vein or simultaneously from both the carotid artery and ruminal vein. Though several acids were labeled with C14, ß-hydroxybutyrate exhibited the highest specific activity. Ruminal vein blood contained over twice as much ß-hydroxy-butyrate as did blood from the carotid artery. The concentration of n-butyrate in ruminal vein blood was frequently lower than that of iso-butyrate, even though the ratio of these two acids in the rumen fluid was approximately 7:1. This suggests that ß-hydroxybutyrate is a normal intermediate in the metabolism of n-butyrate absorbed from the rumen and that the rumen epithelium is a major site of this conversion. The lactate of ruminal vein blood was slightly greater in concentration but several times higher in specific activity than lactate of arterial blood. Glucose from both liver and muscle glycogen was labeled with C14 predominantly in Carbons 3 and 4, the ratio of labeling between these two carbons being approximately 1:1.

FOOTNOTES

1 This investigation was supported in part by a research grant, GM-08506, from the National Institute of General Medical Sciences, Public Health Service.

2 Present address: Nutrition Section, Department of Animal Science, North Carolina State of the University of North Carolina, Raleigh.






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Copyright © 1965 by the American Dairy Science Association ®.