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Growth Hormone-Induced Ketosis in the Cow¹

School of Veterinary Medicine, University of Pennsylvania, Kennett Square

ABSTRACT

Crystalline bovine growth hormone (GH) in daily doses of 1 mg/kg was injected intramuscularly into two lactating cows for ten days starting 2 wk after parturition. In both cows, plasma concentrations of nonesterified fatty acids and acetone-plus-acetoacetate rose during the period of GH administration, and fell after GH administration ceased. Decreased incorporation of acetate-C¹⁴ (injected intracisternally) into milk fat during GH-induced ketosis resembled that seen previously during spontaneous ketosis. Since exogenous GH can induce ketosis in the cow, excessive secretion of endogenous GH could conceivably play a role in the pathogenesis of naturally occurring bovine ketosis.

¹ This work was supported by the U.S. Public Health Service, grant AM-04927 of the National Institute of Arthritis and Metabolic Disease. The growth hormone, Somar, used was a gift from the Armour Pharmaceutical Company, Kankakee, Illinois, through courtesy of Dr. M. E. Davenport.