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Effect of Sodium Chloride Administration on Iodine-131 Retention in Calves^{1, 2,}

Animal Sciences Department

W. V. Kessler and J. E. Christian

Bionucleonics Department, Purdue University, Lafayette, Indiana

ABSTRACT

Alterations of Iodine-131 metabolism in the dairy cow are among the possible countermeasures to milk contamination by this radionuclide. Thus, an increased elimination of Iodine-131 via the urine could decrease its retention in the body and, therefore, its contamination of milk. The administration of chloride has been shown to markedly increase urinary Iodine-131 elimination in rats (2) and dogs (6). Riggs (6) postulated that when chloride excretion was very high (due to chloride administration) the kidney seems less able to differentiate between the two halides. In contrast, in humans the clearance of Iodine-131 was found to be essentially independent of chloride clearance (1, 7).

The purpose of this study was to measure the effect of a single oral dose of sodium chloride on the whole-body retention of Iodine-131 in calves. While this work was in progress, Lengemann (5) reported that a high oral administration of sodium chloride to cows decreased the amount of radioiodine in milk.

¹ Supported by the Division of Radiological Health, Bureau of State Services, Public Health Service, Grant no. RH 00211-02.

² Contribution from the Department of Animal Sciences, Journal Paper no. 2602, Purdue University, Lafayette, Indiana.