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Association between Cerebrospinal Fluid Pressure and Liver Vitamin A Concentration of Holstein Calves Fed Fixed Intakes of Carotene¹

Storrs (Conn.) Agricultural Experiment Station

ABSTRACT

Cerebrospinal fluid pressure (CSFP) is maintained in various mammals and in the chicken within relatively narrow limits, but when vitamin A or its precursor, carotene, or both, is withdrawn from the ration or fed in deficient quantities, CSFP is elevated (5). This change in pressure, one of the first manifestations of vitamin A deficiency in the calf, occurs within the narrowest range of carotene intakes and is proportional to the degree of deficiency of the vitamin (4). Since plasma vitamin A and liver vitamin A, the latter on a logarithmic basis, are linearly related to the logarithm of fixed vitamin A or carotene intake, or both, (1), except at excessive intakes, it follows that the two response variables are associated with CSFP. In plasma vitamin A, evidence for such an association has been given (3). The present communication reports the association between CSFP and liver vitamin A concentration.

Data obtained from 78 Holstein male calves of four experiments conducted during the period 1958–61 were utilized in computation of the statistics reported herein.

¹ Scientific contribution No. 93, Agricultural Experiment Station, University of Connecticut, Storrs. This study was supported in part by grant-in-aid funds provided by PHS Research Grant NB-02108-05 from the National Institute of Neurological Diseases and Blindness, Public Health Service, and Wirthmore Feeds, Inc., Waltham, Massachusetts.