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Persistence of Active Lactic Streptococcal Bacteriophage in Intravenously Inoculated Mice¹

Departments of Dairy Science, Experimental Statistics, and Microbiology and Preventive Medicine, The University of Georgia, Athens

ABSTRACT

Persistence of active lactic streptococcal bacteriophage in internal organs of 104 inoculated Swiss mice was determined. The mice were inoculated intravenously with 0.2 ml each of whey lysate containing the phage. Individual mice were sacrificed at intervals over a period of 91 days and the heart, kidneys, liver, lungs, and spleen assayed for phage content.

Phage was recovered last from the kidneys the 11th day after inoculation, from the liver and lungs the 22nd day, the heart the 24th day, and from the spleen the 85th day. The highest counts were obtained from the spleen and liver and the lowest from the heart.

The analysis of variance of the data on the logarithmic basis indicated that variations associated with the organ, treatment, day, and weight of organ were highly significant at the 1% level. Organ x treatment interaction was not significant.

The regression coefficients of phage count in relation to day indicate the rate of decrease was most rapid in the spleen, followed in order in the liver, kidney, lungs, and heart; but, because of higher initial counts, persistence was greatest in the spleen.

¹ Journal Paper No. 338 of the College Experiment Station, University of Georgia College of Agriculture Experiment Station.