JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 47 No. 3 251-253
© 1964 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paar, G. E.
Right arrow Articles by Hawkins, G. E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Paar, G. E.
Right arrow Articles by Hawkins, G. E.

Secretion of Sulfonamides in Milk Following Intramammary Oral and Parenteral Administrations1

Gary E. Paar, R. Y. Cannon and George E. Hawkins

Department of Dairy Science, Auburn University, Auburn, Alabama

ABSTRACT

Commercial preparations of sulfonamides were administered to lactating dairy cows by one or more routes to determine the duration of their secretion in milk. Neoprontosil injected intramuscularly at the rate of 240 gr/cow was not detected in milk during the first 24-hr post-injection. Intravenous injection of sulfabrom (0.25 gr/lb of body wt), suljex (772 gr/cow), and sulfamerazine (0.5 and 1.0 gr/lb of body wt) resulted in detectable levels of drug residues for maximum periods of 21, 38, 54, and 54 hr, respectively. After intrauterine infusion of sulfaurea (77 gr of sulfonamides), the drug was detected in milk a maximum of 45 hr. Orally administered sulfonamides, dose in grains/pound body weight, and the maximum period the drugs were detected in milk were: (a) sulfanilamide, 1.0 gr, 86 hr; (b) sulfadiazine, 0.5 gr, 62 hr; and (c) sulfamerazine, 0.5 gr, 60 hr.

Following intramammary infusion of suljex at the rate of 77 gr/quarter, the drug was detected in milk a maximum of 7 hr. Chromatographic determinations indicated that the concentration of sulfamerazine (from suljex) in milk was 4.86 times greater than that of sulfapyridine. After infusion of sulfamerazine as a single drug at the rate of 80 gr/quarter, it was detected in milk for a maximum of 24 hr.

FOOTNOTES

1 This investigation was supported in part by a U. S. Public Health Service Grant, EF-00339.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1964 by the American Dairy Science Association ®.