HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Miller, J. K. Articles by Swanson, E. W. Search for Related Content PubMed Articles by Miller, J. K. Articles by Swanson, E. W.

Comparison of the Metabolism of Sodium Iodide and 3,5-Diiodosalicylic Acid in Dairy Cattle¹

Agricultural Research Laboratory of The University of Tennessee, Oak Ridge, Tennessee³

ABSTRACT

Three cows were dosed orally twice daily with diiodosalicyclic acid (DI¹³¹S) and NaI¹²⁰ plus Ce¹⁴⁴ as a nonabsorbed marker. Ruminal absorption and abomasal secretion of iodine from NaI were greater (P < .01) than from DIS. Below the duodenum, absorption of DIS paralleled that of iodide. Because of reduced abomasal secretion of DIS, fecal excretion of iodide was four times that of DIS. Secretion into milk and thyroid accumulation of iodide were over four times that of DIS.

Four additional cows fed 15 mg iodine daily as KI or DIS received single doses of NaI¹³¹ in one period followed by DI¹³¹S in a later period. Average seven-day I¹³¹ excretions from NaI compared to DIS doses were 13.5 and 3.3% (P < .01) in milk, 31.5 and 81.0% (P < .01) in urine, and 39.0 and 7.7% (P < .01) in feces. Cows fed KI excreted more I¹³¹ from the NaI¹³¹ dose in milk and feces and less in the urine than those fed DIS. However, iodine supplements had no effect (P > .25) on excretion of the DI¹³¹S dose. Thyroxine metabolism was not influenced by DIS fed to two cows dosed with I¹³¹-labelled thyroxine in a single reversal test.

It is suggested that urinary excretion as the glycine conjugate rapidly cleared DIS from the system. As a result, the abomasum, thyroid, and mammary gland had less iodine available from DIS than from NaI. The stability of DIS in trace-mineralized salt must be weighed against its relative unavailability compared to iodide.

¹ This manuscript is published with the permission of the Director of the University of Tennessee Agricultural Experiment Station, Knoxville.

² Dairy Department, North Dakota State University, Fargo, North Dakota.

³ Operated by the Tennessee Agricultural Experiment Station for the U. S. Atomic Energy Commission under Contract No. AT-40-1-GEN-242.