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Effect of Leucine and Valine on Ketogenesis in the Ruminant^{1, 2,}

Department of Dairy Science, University of Wisconsin, Madison

ABSTRACT

A study was made of the intermediary metabolism of L-leucine and DL-valine in the goat. The ketogenic nature of leucine was demonstrated both in the fasted and fed animal. Following intraruminal or intravenous infusion, leucine disappeared very rapidly from the blood and actually depressed the plasma level of amino acids in the fasted animal.

Antiketogenic and glucogenic effects of valine were demonstrated following intraruminal or intravenous infusion.

Effects similar to those of leucine and valine were exhibited by their metabolic intermediates, the branched-chain volatile fatty acids. The marked ketogenic effect of isovaleric acid was demonstrated following intraruminal infusion. There was a triphasic response in blood glucose similar to that occurring when other ketogenic fatty acids are placed in the rumen.

Isobutyric acid exhibited marked glucogenic and antiketogenic properties when placed in the rumen.

¹ Published with the approval of the Director of the Agricultural Experiment Station.

² These data are part of a thesis presented by the senior author to the University of Wisconsin in partial fulfillment of the requirements of the degree of Master of Science.

³ Recipient of a National Science Foundation Fellowship.