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Elimination of 2-Methyl-4-Chlorophenoxyacetic Acid and 4-(2-Methyl-4-Chlorophenoxybutyric) Acid in the Urine from Cows

Departments of Entomology and Animal Husbandry, Cornell University, Ithaca, New York

ABSTRACT

The herbicides 2-methyl-4-chlorophenoxyacetic acid (MCP) and 4-(2-methyl-4-chlorophenoxybutyric) acid (MCPB) are used for broadleaf weed control in forage and other crops. It is, therefore, essential to know the mode of metabolism of these compounds when ingested by cows as herbicide residues on forage.

Using electron affinity gas chromatography, the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was found in the urine of Holstein steers fed either 2,4-D or 4-(2,4-dichlorophenoxybutyric) acid [4-(2,4-DB)] (3). In the work reported, MCP was found in the urine of animals fed MCP or MCPB.

EXPERIMENTAL PROCEDURE

Two Holstein cows were catheterized and fed 2.5 and 5 ppm (based on a 50-lb daily ration) of MCPB on November 1, 1963. The pure herbicide in absolute ethyl alcohol was mixed with the grain. A Holstein steer was fed 5 ppm (based on a daily ration of 50 lb) of MCP on October 8, 1963. The pure herbicide in absolute ethyl alcohol was similarly mixed with the grain.