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Host-Bacteriophage Relationships as Influenced by Antibiotics¹

Department of Dairy Technology, The Ohio State University, Columbus

ABSTRACT

The effect of sublethal concentrations of selected antibiotics on the bacteriophage-host relationship of Streptococcus lactis C10 and bacteriophage C10 was studied by means of single-step growth curves.

The addition of penicillin, terramycin, and nisin to the adsorption mixture resulted in average burst sizes of 84, 16, and 30, respectively, compared to 42 bacteriophage particles per infected bacterium in the absence of antibiotics. The corresponding latent periods were 20, 24, 23, and 16 min.

The reproduction of new phage particles may be hastened or retarded by exposure of susceptible cells to sublethal concentrations of antibiotics.

¹ Article 8-62, Department of Dairy Technology. Supported by a grant from the U. S. Public Health Service (National Institutes of Health).