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Procaine Penicillin G in Milk Following Intramuscular Injections

Animal Industry Department, Southern Illinois University

G. R. Krawczyk

Ralston Purina Company, St. Louis, Missouri

ABSTRACT

Due to the hypersensitivity of some humans to even minute quantities of antibiotics, milk contaminated with antibiotics is considered unfit for human consumption (6). Extensive research has been conducted on the duration of secretion of antibiotics in milk following intra-mammary infusion (1, 4, 12), upon which extensive educational programs have been based to insure an antibiotic-free milk supply. Until recent studies (3, 5, 11, 14–16), information regarding the duration of secretion of antibiotics in milk following intramuscular injections of these drugs has been meager. Earlier work (7–10, 13) indicated that the concentration of antibiotics and the duration of time they persist in milk following treatment is dependent upon the dosage, stage of lactation, type of suspension vehicle, type of antibiotic, and physical condition of the udder. Due to conflicting reports on the time that antibiotics persist in milk following administration of these drugs, a study was designed to determine the time which must elapse from injection until the milk is salable.