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Excretion of 3-Cl-Aniline and Isopropyl-N-(3-Chlorophenyl) Carbamate (CIPC) in the Milk and Urine of Dairy Cows Fed CIPC¹

Departments of Zoology and Entomology and Dairy Science, Ohio Agricultural Experiment Station, Wooster

ABSTRACT

No isopropyl-N-(3-chlorophenyl) carbamate (CIPC) or 3-Cl-aniline residues were found in the milk when dairy cows were fed CIPC twice daily at the rates of 1, 5, and 25 ppm during a 4-wk period. Also, no residues of CIPC or 3-Cl-aniline were found in milk during the 48-hr period following ingestion of 100 ppm CIPC in a single feeding. However, 3-Cl-aniline was found in the urine 3 hr after feeding 100 ppm CIPC and during the subsequent 12 hr. The minimum detectable levels of the analytical method were 0.05 ppm CIPC and 0.03 ppm 3-Cl-aniline. The feeding of CIPC in this investigation produced no measurable effect on the physiology of the cows or their milk production.

¹ State Special Project No. 111, supported in part by a grant from the Pittsburgh Plate Glass Company, Chemical Division, Barberton, Ohio. Contribution to Regional Project NC-33, Pesticide Residues on or in Pood, Feed, and Forage Crops (Their Magnitude, Character, and Persistence).