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Journal of Dairy Science Vol. 46 No. 10 1114-1117
© 1963 by American Dairy Science Association ®
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Metabolism of Diiodosalicylic Acid in Dairy Calves1

P. W. Aschbacher2, J. K. Miller and E. G. Gragle

Agricultural Research Laboratory, University of Tennessee, Oak Ridge3

ABSTRACT

Diiodosalicylic acid (DIS) as a source of iodine has been investigated with dairy calves in three, seven-day balance trials involving1 four animals per trial. Two animals in each trial were dosed orally with I131-labelled diiodosalicylic acid (DI131S) and two with I131 as iodide (I131-). Absorption from the gut, excretion patterns, thyroidal uptake, and the relationship of DIS and plasma proteins were studied. Peak levels of radioactivity occurred in plasma approximately 24 hr post-dosing with DI131S, at which time over 90% of the activity was protein-bound. With I131-, peak levels of activity occurred at approximately 8 to 10 hr, with less than 1% of the activity being protein-bound. Urinary excretion of activity averaged 83.2 and 46.1% (P < 0.01) and fecal excretion averaged 6.4 and 20.0% (P < 0.01) of the dose with DI131S and I131-, respectively. Although fecal excretion of activity from DI131S was significantly lower, total excretion was greater (P < 0.01). Thyroid uptake of I131 in four calves dosed with DI131S (two iv and two oral) averaged 5.5%, compared to 26.8% in two calves dosed orally with I131-.

FOOTNOTES

1 Published with the permission of the Director of the Tennessee Agricultural Experiment Station, Knoxville.

2 Present address: Dairy Department, North Dakota State University, Eargo.

3 Operated by the Tennessee Agricultural Experiment Station for the U. S. Atomic Energy Commission under Contract No. AT-40-1-GEN-242.






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Copyright © 1963 by the American Dairy Science Association ®.