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Concentration of Penicillin in Milk from Noninfused Quarters Following Infusion of One Quarter¹

Department of Dairy Science Auburn University Auburn, Alabama

ABSTRACT

Penicillin has been reported to occur in milk from noninfused quarters of cows in which one or more quarters were infused (2, 4, 8). The observation by Blobel (2), that penicillin diffused from the treated to the nontreated quarters, appears to contradict findings of the classical studies referred to by Smith (9), in which dye and radioactive barium were employed. Both of these studies, and others which have been reviewed by Albright et al. (1) indicated that no diffusion occurs between quarters of the udder of cows. Consequently, further study on penicillin transfer between quarters seemed desirable.

During a study of factors affecting the concentration and duration of penicillin secretion in milk from infused quarters, milk samples were collected from the noninfused quarters. Penicillin preparations employed were: (A), Procaine penicillin G in sesame oil with 2% aluminum monostearate; and (B), Aqueous potassium penicillin G. A fore quarter of each of 18 cows, six cows per treatment, was infused at the PM milking, as follows: (a), 300,000 units of Preparation A; (b), 100,000 or (c) 300,000 units of Preparation B.

¹ Supported in part by U. S., P.H.S. Grant EF0039.