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Effect of Vitamin A Deficiency on Efflux of Sodium Thiocyanate from Cerebrospinal Fluid

Dairy Cattle Research Branch, U. S. Department of Agriculture, Beltsville, Maryland

ABSTRACT

Vitamin A deficient and normal Holstein calves were studied to provide information on the mechanism of the cerebrospinal fluid (CSF) pressure increase occurring in vitamin A deficiency. Thiocyanate (SCN) was injected into the cisterna magna and the concentration of this marker remaining in the CSF was estimated at 30, 60, 90, 120, 180, 240, and 300 min post-injection. Comparison of the SCN concentrations during the first 90 min showed similar values. Samples taken thereafter exhibited higher values in the deficient animals. Graphical interpretation of these data resulted in SCN disappearance rates of 3.02 x 10^–3 mg/ml/min for the deficient group and 5.44 x 10^–3 mg/ml/min for the control animals. This difference would indicate a lesser reabsorption of the CSF in the deficient calves and could also explain the higher CSF pressures in the deficient animals—225 mm as compared to 96 mm.