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Lipid Exchange between Bovine Serum Lipoproteins In Vitro^1,2

Department of Dairy Science, Pennsylvania Agricultural Experiment Station, University Park

ABSTRACT

Lipid incorporation and exchange in whole blood by bovine serum lipoproteins of high. (D > 1.063) and low density (D < 1.063) have been studied in vitro. The high-density lipoproteins evinced a strong binding capacity for cholesterol and phospholipids. Low-density lipoproteins showed a great affinity for cholesteryl palmitate and tripalmitin. Palmitic and linoleic acids were bound almost entirely by serum proteins. Cholesterol exchanged between high- and low-density lipoproteins, rate of transfer being in the direction of the former. Cholesteryl palmitate moved only from low- to high-density lipoproteins. Tripalmitin and phospholipid did not transfer in either direction. Palmitic and linoleic acids transferred from both lipoprotein groups to the serum proteins. Cholesterol and tripalmitin labeled lipoproteins of high and low density lost a small amount of radioactivity to the blood cells.

¹ Authorized for publication October 20, 1961 as Paper No. 2610 in the Journal Series of the Pennsylvania Agricultural Experiment Station.

² Supported in part by the U. S. Public Health Service (H3632).

³ Present address: Department of Dairy Husbandry, University of Minnesota, St. Paul.