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Journal of Dairy Science Vol. 45 No. 10 1256-1258
© 1962 by American Dairy Science Association ®
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Biological Assay of Thyroprotein1

C. W. Turner and T. R. Bauman

Department of Dairy Husbandry, University of Missouri, Columbia

ABSTRACT

A new method for the biological assay of thyroidal substances based upon the determination of the thyroxine secretion rate (TSR) of rats is suggested. The mean TSR of a group of rats is first determined by thyroxine replacement. Thyroprotein is then injected subcutaneously in amount sufficient to block thyroidal-I131 release in the individual rats. Biological estimation of thyroidal activity in five samples of thyroprotein indicated that samples contained 42, 27, 45, 31, and 53% more activity than chemical estimation of 1% thyroxine. It was suggested that the increased biological activity might be due to slower absorption of thyroxine from the injection site or to the presence of significant amounts of triiodothyronine in thyroprotein.

FOOTNOTES

1 Contribution from Missouri Agricultural Experiment Station. Journal Series No. 2454. Approved by the Director.

2 Aided in part by a grant from U. S. Atomic Energy Commission Contract No. AT(11-1)-301.






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