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Metabolism of Radiostrontium in Young Pigs and in Lactating Rats Fed Stable Strontium¹

College of Veterinary Medicine University of Illinois and Illinois Agricultural Experiment Station, Urbana

ABSTRACT

Lactating rats fed stable strontium retained more radiostrontium, and carcasses of their young contained significantly more radiostrontium, than the lactating rats and their offspring which did not receive stable strontium. Results of these experiments were compared to the effect of stable strontium on the absorption of radiostrontium observed in other species. The effect of feeding stable strontium for ten days before the radiostrontium meal was not significantly different from feeding stable strontium simultaneously with radiostrontium.

Feeding Hampshire pigs 21 days of age a ration containing 0.67% stable strontium, with 0.16 or 0.89% calcium, increased the amount of radiostrontium in the feces fourfold during the seven days after administration of radiostrontium. The amount of the absorbed radiostrontium appearing in the urine of the pigs fed strontium was about twice that of pigs not receiving strontium. The concentration of calcium in the diet had no marked effect on the quantity of radiostrontium in the urine and feces. Feedingstable strontium reduced the skeletal retention of radiostrontium three- to fourfold.

¹ Study submitted as partial fulfillment of the requirements for the degree of Master of Science in Veterinary Medical Science.

² Present address: Department of Pharmacology, Physiology, and Biochemistry, School of Veterinary Medicine, University of California, Davis.

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