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Association Between Cerebrospinal Fluid Pressure and Plasma Vitamin A Concentration of Holstein Calves Fed Fixed Intakes of Carotene¹

Storrs (Conn.) Agricultural Experiment Station, Storrs, Conn.

H. W. Norton

Illinois Agricultural Experiment Station, Urbana, Ill.

ABSTRACT

Cerebrospinal fluid (CSF) pressure of normal cattle to 2 yr. of age, measured at the atlanto-occipital articulation, averaged 105 mm. saline (0.85%), with a range of values between 80 and 150 mm., and was unaffected by age, Sykes and Moore (9). When graded levels of carotene intake were fed to calves, increases in pressure above 120 mm. occurred at intakes below 30 of carotene per pound of live weight per day for Ayrshires and Holsteins, and below 34 and 32 , respectively, for Guernseys and Jerseys (6, 7). The increased CSF pressure appeared to be the first change occurring in experimentally produced vitamin A deficiency in the calf and several other species, as reviewed recently (2). Also, plasma vitamin A concentrations, under conditions of fixed carotene intake, were proportional to the logarithm of carotene intake (10), thus indicating a possible association between CSF pressures and plasma vitamin A concentrations.

¹ This study was supported in part with grant-in-aid funds provided by the National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, grant B-2108, as well as with funds provided by Wirthmore Feeds Inc., Waltham, Mass.