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A Macroglobulin (12 S) Agglutinin for Brucella Bovine Milk^{1, 2,}

University of Minnesota St. Paul 1, Minnesota

ABSTRACT

Since milk from cattle infected with Brucella abortus may contain specific agglutinins for Brucella, milk is now widely used in several presumptive tests to detect brucellosis-suspicious herds. In the brucellosis eradication program, some herds have been encountered in which the milk of a single animal reacted in high dilution to the Ring Test (13), yet blood serum from these animals did not give significant reactions to the tube agglutination test (1) and repeated attempts failed to isolate Brucella from the milk of these individual cows. Studies to determine the nature and cause of this phenomenon resulted in the isolation of a macroglobulin (12 S) agglutinin for Brucella from milk and the development of a procedure which appears to differentiate this agglutinin from those observed concurrently with the isolation of Brucella abortus.

The 12 S Brucella agglutinating component has been isolated from two nonvaccinated cows (No. 2002 and 2159) of the type described above, which were obtained from herds with a history of no Brucella infection during the previous 4 yr.

¹ Paper No. 4573. Scientific Journal Series, Minnesota Agricultural Experiment Station. These studies were made possible in part by a grant from the Animal Disease and Parasite Research Division, Agricultural Research Service, USDA.

² The data in this paper are to be included in a thesis to be submitted by A. J. Kenyon to the University of Minnesota in partial fulfillment of the requirements for the Ph.D. degree.

³ College of Veterinary Medicine.

⁴ Department of Agricultural Biochemistry.

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