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Journal of Dairy Science Vol. 44 No. 12 2278-2282
© 1961 by American Dairy Science Association ®
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Evidence for in Vivo Conversion of C21 Steroids to C19 Androgens in the Bovine1

W. R. Miller2, 3, and C. W. Turner

Department of Dairy Husbandry, University of Missouri, Columbia

ABSTRACT

The biosynthetic transformation of progesterone to fecal androgen (androstenedione) in the bovine has been shown. The present study reports the biosynthetic transformation of pregnenolone and 17{alpha}-hydroxyprogesterone to fecal androgen. Following the injection of pregnenolone into the male and female bovine, the chick comb response test demonstrated a significant formation of fecal androgens in the male and a significant increase in fecal androgens in the female. Following the injection of 17{alpha}-hydroxyprogesterone into the female bovine, androgen biosynthesis was evidenced by the excretion of a significant amount of fecal androgens as measured by the chick comb response test.

In vitro studies with various mammalian tissues have documented a pathway for androgen biosynthesis involving the following sequence: pregnenolone -> progesterone -> 17{alpha}-hydroxyprogesterone -> androstenedione. The cumulative results of the experiments on bovine androgenesis provide in vivo evidence indicating that androgen biosynthesis in the bovine, as in many other species, occurs via the same pathway.

The experimental evidence demonstrates further the major importance of an hepatoenteric pathway for the elimination of the C19 androgen metabolites of these C21 hormones.

FOOTNOTES

1 Contribution from Missouri Agricultural Experiment Station Journal Series No. 2177. Approved by Director.

2 Postdoctoral Research Fellow of the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Public Health Service.

3 With the technical assistance of Mary E. Powell.






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Copyright © 1961 by the American Dairy Science Association ®.