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Concentrations and Percentage Recovery of Furacin in Milk Following Intramammary Infusions¹

Dairy Science Department, Auburn University, Auburn, Alabama

ABSTRACT

Four experiments involving 106 quarters of the udder of dairy cows were carried out to determine the rate and cause of disappearance of furacin from milk following intramammary infusions.

In Trial 1, milk from 43 quarters contained only traces (< 0.5 p.p.m.) of this antibacterial agent at the first (14 hr.) and second (24 hr.) post-infusion milkings. In subsequent trials it was found that the mean concentration and mean percentage recovery of furacin in milk decreased at a rapid rate as the interval between infusion of the drug and milking out of the gland was lengthened. Concentrations and recoveries of the drug were highest in milk withdrawn 1 to 2 hr. post-infusion. Rate of disappearance of furacin in milk varied with individual cows. A spectral analysis of milk filtrates did not yield positive evidence that furacin infused into the mammary glands was metabolized to reduced furacin, as had been reported for in vitro incubations with other biological preparations. It is postulated that the disappearance of detectable furacin in milk from infused quarters is due to the absorption of the drug or its metabolites into the blood stream or the formation of a chemical complex between furacin and milk proteins.

¹ This investigation was supported in part by a U. S. Public Health Service grant.