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Journal of Dairy Science Vol. 43 No. 10 1499-1504
© 1960 by American Dairy Science Association ®
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Effect of Promazine Hydrochloride and Chlorpromazine Hydrochloride on the Motility and Fertility of Bovine Semen

R. H. Foote and Linda C. Gray1

Department of Animal Husbandry, Cornell University, Ithaca, New York

ABSTRACT

Promazine hydrochloride (Sparine) and chlorpromazine hydrochloride (Thorazine) were incorporated in 20% egg yolk extenders of the CU-16 type at levels as high as 2,000 µg. per milliliter of extender. None of the levels of promazine tested improved sperm survival, and the highest levels of both drugs were spermicidal (P < 0.01). Survival of spermatozoa was improved by the replacement of sulfanilamide (SA) with 200 µg. chlorpromazine per milliliter in CU-16 extender, but chlorpromazine was only partially effective in replacing SA in CUE extender. The same level of chlorpromazine was slightly spermicidal when added to a 50% yolk-citrate-sulfanilamide extender, and markedly spermicidal when added to heated skimmilk.

The 60- to 90-day nonreturns for semen extended in the CU-16 extender, modified by replacing SA with 200 µg. of chlorpromazine per milliliter, averaged 73.9% compared to 70.3% for the control 50% yolk-citrate-sulfanilamide extender. Subsequently, this modified CU-16 extender was compared with the sulfanilamide-containing standard CU-16 and CUE extenders. The number of first services and 60- to 90-day per cent nonreturns for the three extenders, respectively, were 4,796 and 73.7, 4,871 and 74.9, and 4,650 and 74.9 (P > 0.05). While all three extenders gave highly acceptable fertility, there appears to be no advantage in replacing sulfanilamide with chlorpromazine in the extenders used in these experiments.

FOOTNOTES

1 Present address: Department of Dairy Science, Washington State University, Pullman.






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