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Inulin Renal Clearance in Dairy Cattle^{1, 2,}

Department of Dairy Science, New Jersey Agricultural Experiment Station, Sussex

ABSTRACT

A practical method for determining inulin renal clearance (the glomerular filtration rate of the kidneys) and the volume of the extracellular fluids of cattle is described, based on the measurement of the kinetics of inulin distribution and disposal after intravenous infusion. For these purposes the blood level of inulin was determined at varying time intervals up to 2 hr. after infusion.

Inulin had reached equilibrium with the extracellular fluids of the body in approximately 45 min. (half-time of about 6 min.). The volume of the distribution of inulin was calculated to be 29.3 and 15.3% of body weight in a calf and cow, respectively. The inulin fractional clearance rate in a calf and cow were 0.0089 and 0.0168 per minute, while the corresponding inulin volume clearances were 2.61 and 2.57 ml. per minute per kilogram of body weight, respectively.

¹ Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers—The State University, New Brunswick. This work was supported in part by a grant from Merck Sharp & Dohme Research Laboratories, Division of Merck & Company, Rahway, New Jersey.

² This study was part of a Northeast Regional Researeh Project (NE-41, Endocrine Factors Affecting Reproduction and Lactation in Dairy Cattle), a cooperative study involving agricultural experiment stations in the Northeastern Eegion and supported in part by regional funds of the United States Department of Agriculture.

³ Present address: Department of Dairy Husbandry, University of Missouri, Columbia.