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Effect of Synthalin a on Renal Function in Dairy Bull Calves as Measured by Phenolsulfonphthalein Clearance¹

Department of Dairy Science, New Jersey Agricultural Experiment Station, Sussex

ABSTRACT

Synthalin A (decamethylenediguanidine) is a toxic, hypoglycemic agent which has been reported to cause histological changes in the liver, kidneys, and alpha cells of the Islets of Langerhans, and also to depress hepatic function in dairy bull calves. Five Holstein bull calves (eight days of age) were treated with a single intramuscular injection of synthalin A at the rate of 2.2 mg. per kilogram of body weight. Renal function as measured by both phenolsulfonphthalein fractional and volume clearances was depressed to approximately 35% of normal within 16 hr., and had returned to near-normal values within seven days. Correspondingly, plasma glucose levels decreased from a mean preinjection level of 85.6 mg. % to 32.8 mg. % at 16 hr. after injection, and returned to normal levels again within 66 hr. after injection. These effects were significant statistically (P < 0.01).

¹ Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers—The State University, New Brunswick. This work was supported in part by a grant from Merck Sharp & Dohme Research Laboratories, Division of Merck & Company, Rahway, New Jersey.

² Present address: Department of Dairy Husbandry, University of Missouri, Columbia.