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Effects of Various Amounts of Chlortetracycline in the Rations of Lactating Dairy Cattle

Agricultural Division, American Cyanamid Company, Princeton, New Jersey

ABSTRACT

Aureomycin¹ (chlortetracycline) was fed to lactating dairy cattle at levels of 0, 0.1, 0.5, and 1.0 mg. per pound of body weight per cow per day for a period of 2 wk. Although two of the four cows in each of the two groups receiving the higher doses showed slightly depressed appetites shortly after the trial was started, feed consumption returned to normal after a brief period of adjustment. During this adjustment period, milk production also was reduced, but generally returned to similar relative levels of the controls within a few days. No marked clinical effects were noted in the group receiving 0.1 mg. per pound of body weight, and milk from these cows was negative for the presence of the antibiotic. Slight amounts of chlortetracycline were found in the milk of cows on higher feeding levels and these slight amounts were eliminated from all cows' milk by 48 hr. after the feeding of the antibiotic had been discontinued.