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Journal of Dairy Science Vol. 42 No. 5 856-862
© 1959 by American Dairy Science Association ®
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Effect of High-Level Administration of Chlortetracycline at Birth on the Health and Growth of Young Dairy Calves1

L. L. Rusoff, A. H. Cummings, E. J. Stone and J. E. Johnston

Louisiana Agricultural Experiment Station, Baton Rouge

ABSTRACT

Therapeutic and nutritional aspects of the effect of chlortetracycline (CTC) on health, growth, and feed efficiency of 64 newborn Holstein and Jersey female and male calves were studied. Daily levels of either 0, 250, 500, or 1,000 mg. of the antibiotic administered for the first three days of life resulted in a reduction in enteritis and death in those calves receiving chlortetracycline, with the 250-mg. level being as effective as the two higher levels. The high-level three-day treatments of the antibiotic to dairy calves at birth did not result in any subsequent stimulation in growth up to 16 wk. of age.

Starting at four days of age, the feeding of daily nutritional levels of 50 mg. of chlortetracycline to one-half of the calves in each group produced a significant (P < .05) increase in growth of approximately 18% at 16 wk. of age when compared to the control subgroups, regardless of the first three-day high level treatments. An increase in feed consumption and in feed efficiency in the antibiotic-fed calves also was noted.

The mode of action of antibiotics in stimulating growth in young calves can not be explained entirely by a reduction in "disease level," and probably involves a metabolic or endocrine effect.


FOOTNOTES

1 This investigation was supported in part by a grant from the Research Division, American Cyanamid Co., Pearl River, N. Y.







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Copyright © 1959 by the American Dairy Science Association ®.