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Journal of Dairy Science Vol. 42 No. 3 545-549
© 1959 by American Dairy Science Association ®
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Normal Standards, Repeatability, and Precision of Phenolsulfonphthalein Clearance Measures for Renal Function in Dairy Cattle1

R. R. Anderson2 and J. P. Mixner

Department of Dairy Industry, New Jersey Agricultural Experiment Station, Sussex

ABSTRACT

Twenty-eight dairy bull calves and 24 dairy cows were used in trials to determine normal standards for phenolsulfonphthalein (PSP) fractional clearance, PSP volume of distribution, and PSP volume clearance as measures of renal function. The mean PSP fractional clearances per minute were 0.0250 and 0.0431, the PSP volumes of distribution were 31.3 and 19.0% of body weight, and the corresponding PSP volume clearances as milliliters per kilogram of body weight were 7.48 and 8.00 in calves and cows, respectively.

The repeatability and precision of the various PSP clearance measures were low, as determined from variability found in trials conducted in 20 bull calves and 22 cows on two successive days. The reason for this was not determined.

It was suggested that both PSP fractional clearance and PSP volume clearance measures should be used as criteria of renal function.

FOOTNOTES

1 Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, the State University of New Jersey, Department of Dairy Science, New Brunswick. This work was supported in part by a grant from Merck Sharp & Dohme Research Laboratories, Division of Merck & Company, Rahway, New Jersey.

2 Present address: Department of Dairy Husbandry, University of Missouri, Columbia.






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Copyright © 1959 by the American Dairy Science Association ®.