HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wing, J. M. Search for Related Content PubMed Articles by Wing, J. M.

Effect of Procain Penicillin, Potassium Para-Amino Salicylate, and Isoniazid on Young Calves¹

Department of Dairy Science, Florida Agricultural Experiment Station, Gainesville

ABSTRACT

Para-amino salicylic acid (PAS) and isoniazid have influenced the effect of wide-spectrum antibiotics in young calves. PAS appeared to counteract the effect of chlortetracycline (4). Isoniazid enhanced the effect of chlortetracycline but counteracted the effect of oxytetracycline (3). The nature of this interaction is not clear, but it may have been due to a change in the type of microorganisms affected. It seemed possible, therefore, that the influence of these substances could enhance the value of narrow-spectrum antibiotics. Penicillin was chosen for this study because reports concerning the nutritional use of this antibiotic are highly variable (1).

Twenty-four new-born calves, four Holsteins and 20 Jerseys, were assigned to four comparable groups. All calves were removed from their dams at birth and confined in indoor, individual metal pens with concrete floors. The bedding material was wood shavings and was changed daily.

Dry mixed concentrates and chopped pangola grass hay were fed in removable metal containers.

¹ Florida Agriculture Experiment Station Journal Series, No. 727.