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New Approach to the Problem of Assessing Adrenal Cortical Activity in Dairy Cattle¹

New Jersey Agricultural, Experiment Station, Sussex

ABSTRACT

The problem of assessing adrenal cortical activity is well characterized by the work of Sandberg et al. (8), who reported that human patients had elevated levels of plasma 17-hydroxycorticosteroids after surgery and at the same time had depressed rates of peripheral metabolism or degradation of hydrocortisone. Tyler et al. (10) have shown that impaired liver function was directly related to the postoperative rises in plasma levels of 17-hydroxycorticosteroids in man. This illustrates the need for a measure of adrenal cortical activity which combines the separate aspects of the level of circulating hormone and the rate of peripheral metabolism or turnover of the hormone into a single measure.

Ingbar and Freinkel (3) have presented a method for estimating the daily rate of thyroid hormone degradation and synthesis (D) in humans. To determine D, the following constants were derived: normal level of plasma protein-bound iodine (PBI) as a measure of the level of circulating thyroxine in its volume of distribution; fractional rate of turnover per day of extrathyroidal thyroxine (k), as derived from use of tracer doses of L-thyroxine tagged with I¹³¹; and thyroxine distribution space or volume (TDS).

¹ Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, the State University of New Jersey, Department of Dairy Science, New Brunswick. This work was supported in part by a grant from Merck Sharp & Dohme Research Laboratories, Division of Merck & Company, Rahway, New Jersey.