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Sources of Progestins in the Pregnant Cow^{1, 2,}

Departments of Dairy Science, Veterinary Physiology and Pharmacology, and Veterinary Clinical Medicine and Surgery, State College of Washington, Pullman

ABSTRACT

Progesterone and ⁴-pregnene-20ß-ol-3-one were assayed, using paper chromatography and ultraviolet spectra. Neither progestin was detected in the placenta or uterine venous blood of a Jersey heifer pregnant 258 days. The blood, adrenals, and testis of the fetus were negative for progestins. The ovaries contained an estimiated 50 µg. of progesterone (adrenals < 10 µg.) and 5 µg. of ⁴-pregnene-20ß-ol-3-one. Six additional assays of cow placentae have been negative for progesterone. Corpora lutea (five assays involving three each) contained approximately 90% of the progesterone and all of the ⁴-pregnene-20ß-ol-3-one found in the ovaries of cows. The remaining progesterone was in the ovaries from which the corpora lutea were removed. Progesterone ranged from 6.4 to 15.2 µg/g in luteal tissue. The lowest concentration was from late-pregnant and the highest from nonpregnant cows.

¹ Scientific Paper 1737, Washington Agricultural Experiment Stations, Pullman. Project 1359.

² This investigation was supported in part by funds for biological and medical research by the State of Washington, Initiative Measure No. 171 (Biol. & Med. 195).