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A Comparison Between the Serum Inorganic Iodine Levels of Feeding Potassium and Cuprous Iodide, and Copper Retention

Pharmaceutical Research Section Jensen-Salsbery Laboratories, Inc., Kansas City, Missouri

ABSTRACT

The oral administration of cuprous and potassium iodide to calves for seven days did not result in significant differences in blood serum, inorganic iodine levels. The elimination rate of iodine for both compounds was the same, being a linear function of the log serum inorganic iodine level with time. There was no evidence of toxicity from either iodine or from copper. Cuprous iodide was more palatable than potassium iodide. Editor.

Experiments by Long et al. (8) have shown that feeding 2.816 g. potassium iodide per day, administered at two-day intervals, is sufficient to maintain a high therapeutic serum inorganic iodine level constantly, for the systemic treatment for actinomycosis and other mycotic infections in cattle. Lewis (7) showed that very high levels of serum inorganic iodine could be obtained by feeding one gram cuprous iodide to a thyroidectomized Jersey bull. Mittler and Benham (9) found that cuprous iodide has greater efficacy than potassium iodide in protecting the thyroid gland of albino rats from enlargement.