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Journal of Dairy Science Vol. 40 No. 8 977-980
© 1957 by American Dairy Science Association ®
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Determination of Liver Function, Plasma and Blood Volumes in Ketotic Cows, Using Bromsulphalein1

W. G. Robertson2, J. P. Mixner, W. W. Bailey3 and H. D. Lennon, Jr.

New Jersey Agricultural Experiment Station, Sussex

ABSTRACT

Liver function in six ketotic cows was markedly depressed, as compared to five normal control cows, as shown by the bromsulphalein (BSP) fractional clearance method, being 0.089 and 0.192, respectively. The differences in these values were highly significant statistically (P<0.01). These findings are in accordance with prior histopathological evidence for liver damage in ketosis cows. Plasma protein-bound iodine levels were also lower in the ketosis cows, 2.53 µg. %, as compared to 3.52 µg. % for the controls, the difference being statistically significant at the five per cent level, confirming our earlier observation. The blood hematocrits, plasma and blood volumes per kg. of body weight were 35.6 and 37.0%; 38.1 and 47.8 ml., and 57.2 and 73.1 ml., for the control and ketosis cows, respectively. Although in all instances the values for the ketotic cows were higher, none of the differences was statistically significant.

FOOTNOTES

1 Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, the State University of New Jersey, Department of Dairy Industry, New Brunswick. This work was supported in part by a grant from Merck Sharp & Dohme Research Laboratories, Division of Merck & Company, Rahway, New Jersey.

2 Present address: Veterinary Research Department, Schering Corporation, Bloomfield, New Jersey.

3 Practicing veterinarian, Sussex, New Jersey.






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Copyright © 1957 by the American Dairy Science Association ®.