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Effect of Synthalin A on Blood Glucose Levels and Liver Function in Dairy Bull Calves¹

New Jersey Agricultural Experiment Station, Sussex

ABSTRACT

Synthalin A caused a marked reduction in bromsulphalein fractional clearance as a measure of liver function and in blood glucose levels in Holstein bull calves, as compared to both normal and starved control animals. Some evidence of liver damage by synthalin A was noted. Results suggested that the hypoglycemia caused by synthalin A may be owing partially to an impairment of gluconeogenic activity of the liver.

¹ Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, the State University of New Jersey, Department of Dairy Industry, New Brunswick. This work was supported in part by a grant from Merck Sharp & Dohme Research Laboratories, Division of Merck & Company, Rahway, New Jersey.

² Present address: Veterinary Research Department, Schering Corporation, Bloomfield, New Jersey.