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Journal of Dairy Science Vol. 40 No. 8 914-921
© 1957 by American Dairy Science Association ®
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Bromsulphalein Fractional Clearance in Dairy Cattle as a Criterion of Liver Function, and the Simultaneous Determination of Volumes of Plasma and Blood1

J. P. Mixner and W. G. Robertson2

New Jersey Agricultural Experiment Station, Sussex

ABSTRACT

The dye, bromsulphalein (BSP), was used in a procedure for the simultaneous determination of liver function, and volumes of plasma and blood in dairy cattle. Bromsulphalein was eliminated from the blood of cattle in an exponential manner, the loge of dye concentration being related to the time after dye administration, in a rectilinear manner. The slope of the regression curve was termed the "BSP fractional clearance," and was defined as the fraction of the total blood plasma volume which was cleared of BSP per minute on an instantaneous basis. Since the BSP distribution volume is the same as the plasma volume, blood and plasma volumes also may be determined using dye dilution techinques.

The mean BSP fractional clearances for nine Holstein bull calves and five lactating Holstein cows were 0.156 and 0.192, respectively. Similarly, the mean plasma values per kg. of body weight were 68.2 ml. and 38.1 ml. for the bull calves and cows, respectively, while the corresponding blood volumes per kg. of body weight were 115.0 ml. and 57.2 ml.

FOOTNOTES

1 Paper of the Journal Series, New Jersey Agricultural Experiment Station, Rutgers University, The State University of New Jersey, Department of Dairy Industry, New Brunswick. This work was supported in part by research grants from Merck Sharp & Dohme Research Laboratories, Division of Merck & Company, Rahway, New Jersey, and Swift and Company, Chicago.

2 Present address: Veterinary Research Department, Schering Corporation, Bloomfield, New Jersey.






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Copyright © 1957 by the American Dairy Science Association ®.